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Sommaires des Revues - Mayo Clinic Proceedings

Mayo Clinic Proceedings

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25-Year Physical Activity Trajectories and Development of Subclinical Coronary Artery Disease as Measured by Coronary Artery Calcium  Voir?

To evaluate 25-year physical activity (PA) trajectories from young to middle age and assess associations with the prevalence of coronary artery calcification (CAC).
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Serum Calcium: A Sudden Cardiac Arrest Risk Factor  Voir?

In this issue, Yarmohammadi et al1 report that low serum calcium levels are independently associated with increased risk of sudden cardiac arrest (SCA) in the community. As part of the Oregon Sudden Unexpected Death Study, with a catchment population of 1 million, patients with SCA were compared with control subjects from the same geographic region with a diagnosis of coronary artery disease to match that among cases. All patients included had available serum electrolyte levels and creatinine clearance values within 90 days of the sudden cardiac death event.

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Serum Calcium and Risk of Sudden Cardiac Arrest in the General Population  Voir?

To evaluate the potential role of low serum Ca levels in the occurrence of sudden cardiac arrest (SCA) in the community.
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20-Year-Old Woman With Postprandial Nausea, Vomiting, and Abdominal Pain  Voir?

A 20-year-old woman who had undergone a corrective spinal operation for scoliosis 6 weeks previously presented with a 3-week history of nausea, vomiting, diarrhea, diffuse abdominal pain, fatigue, and a 6.8-kg weight loss. She stated that the symptoms occurred approximately 20 minutes after eating. The patient reported no melena, hematochezia, fevers, chills, diaphoresis after eating, chest pain, palpitations, shortness of breath, heat or cold intolerance, hair loss, or focal neurologic deficits.

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58-Year-Old Woman With Diarrhea, Weakness, and Memory Loss  Voir?

A 58-year-old woman with a medical history of osteoporosis and Crohn disease presents with her husband for evaluation of chronic diarrhea. Her medications included mesalamine and alendronate, as well as an over-the-counter multivitamin. Recently, Crohn colitis had been diagnosed when colon biopsies revealed scattered colonic inflammation and ulcerations. In addition to unrelenting diarrhea during the months before her presentation, she had experienced a severe functional decline. Six months before her visit, the patient could care for herself and walk several miles at a time without trouble.

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Saddle vs Nonsaddle Pulmonary Embolism: Clinical Presentation, Hemodynamics, Management, and Outcomes  Voir?

To understand the clinical significance, hemodynamic presentation, management, and outcomes of patients presenting with saddle pulmonary embolism (PE).
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My Treatment Approach: Pancreatic Cysts  Voir?

Our treatment approach for either symptomatic or incidentally found pancreatic cysts continues to improve. The true incidence of pancreatic cysts is not known, and pancreatic cystic neoplasms, especially intraductal papillary mucinous neoplasms, are currently most commonly diagnosed and resected. This is a result of increasing awareness, widespread availability of imaging, and better understanding of the nature of pancreatic cysts as well. Recent studies on molecular analysis and devices such as microbiopsy forceps help us better define and select the treatment approach to alleviate symptoms and to prevent malignant tumors while avoiding unnecessary surgery.

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The Diagnosis and Management of Bipolar I and II Disorders: Clinical Practice Update  Voir?

Bipolar disorders, including bipolar I disorder (BP-I) and bipolar II disorder (BP-II), are common, potentially disabling, and, in some cases, life-threatening conditions. Bipolar disorders are characterized by alternating episodes of mania or hypomania and depression, or mixtures of manic and depressive features. Bipolar disorders present many diagnostic and therapeutic challenges for busy clinicians. Adequate management of bipolar disorders requires pharmacotherapy and psychosocial interventions targeted to the specific phases of illness.

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Timing of Intubation in Acute Respiratory Failure Associated With Sepsis: A Mixed Methods Study  Voir?

To analyze bedside clinicians' perspectives regarding the decision process to optimize timing of intubation in sepsis-associated acute respiratory failure.
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46-Year-Old Man With Lower Back Pain  Voir?

A 46-year-old man originally from Vietnam with no known long-term medical conditions presented to a primary care clinic for evaluation of gradually progressive, left-sided, lower back pain accompanied by resolving flulike symptoms. He had a history of episodic back pain dating to his mid-20s, but the cause had never been determined. Unlike his prior episodes, on this occasion he first noticed the discomfort after what he thought was a flulike illness, characterized by fevers, chills, myalgia, malaise, and headache, as well as a 6.8-kg unintended weight loss.

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64-Year-Old Woman With Weakness and Fall  Voir?

A 64-year-old woman presented to the emergency department (ED) after a ground-level fall at home when she attempted to get up from her chair to reach the phone. Her medical history included moderate chronic obstructive pulmonary disease (forced expiratory volume in the first second, 57%), stage 3A chronic kidney disease secondary to hypertension (baseline creatinine level, 1.3 mg/dL), morbid obesity (body mass index, 65), insomnia, depression, and anxiety. Her symptoms had begun approximately 2 weeks earlier, with generalized weakness, light-headedness, and fatigue.

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Highlights from the Current Issue – Audiovisual Summary  Voir?

Karl A. Nath, MBChB, Editor-in-Chief of Mayo Clinic Proceedings, discusses the Editor’s Choice and Highlights articles appearing in the October 2017 issue.
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General Information  Voir?

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Table of Contents  Voir?

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Editorial Board  Voir?

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Beyond Vasoprotection: Statins and Risk Reduction for Community-Acquired Staphylococcus aureus Bacteremia  Voir?

Widely and effectively employed as vasoprotective agents, statins are considered as drugs that may be beneficial in other diseases. One such disease is community-acquired Staphylococcus aureus bacteremia (CA-SAB), as delineated by the study by Smit et al1 in this issue of Mayo Clinic Proceedings. The authors examined the impact of statin use on the risk of CA-SAB in a large patient population in northern Denmark over a 12-year study period.

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Red River and October, Paramecium Pond by Gordon Mortenson  Voir?

Recognizing the contribution art has had in the Mayo Clinic environment since the original Mayo Clinic Building was finished in 1914, Mayo Clinic Proceedings features some of the numerous works of art displayed throughout the buildings and grounds on Mayo Clinic campuses as interpreted by the author.

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Jejunal Gastrointestinal Stromal Tumor  Voir?

A 68-year old man presented with constipation, mild abdominal pain, progressive weakness, and a large abdominal mass filling the left side of the abdomen. His hemoglobin level was 10.5 g/dL (to convert to g/L, multiply by 10.0), hematocrit level was 34% (to convert to proportion of 1.0, multiply by 0.01), and tumor markers were within normal limits. Computed tomography of the abdomen revealed a 10×16-cm heterogeneous mass filling the left side of the abdomen and communicating with the small intestine.

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Books Received  Voir?

Living With Lymphoma: A Patient's Guide, 2nd ed, by Elizabeth M. Adler, 475 pp, with illus, $26.95, Baltimore, MD, Johns Hopkins Press, 2016.
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Clinical Cardio-oncology  Voir?

Type and Scope of Book: This is a multi-authored book that discusses mechanisms and management of cardio-toxicity of cancer therapies.
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Renal Pyelocalyceal Squamous Cell Carcinoma  Voir?

The illustration below shows a cut section of kidney revealing pyelocalyceal squamous cell carcinoma.
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Weight Gain in Women at Midlife: A Concise Review of the Pathophysiology and Strategies for Management  Voir?

Weight gain accompanied by an increased tendency for central fat distribution is common among women in midlife. These changes are a result of aging, decreasing estrogen levels after menopause, and other unique influences in menopausal women that interfere with the adoption of healthy lifestyle measures. Central obesity, in particular, results in several adverse metabolic consequences, including dysglycemia, dyslipidemia, hypertension, and cardiovascular disease. Given that cardiovascular disease is the leading cause of death in postmenopausal women, the importance of weight management in midlife cannot be overemphasized.

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Palliative Care in Neurology  Voir?

Palliative medicine is a specialty that focuses on improving the quality of life for patients with serious or advanced medical conditions, and it is appropriate at any stage of disease, including at the time of diagnosis. Neurologic conditions tend to have high symptom burdens, variable disease courses, and poor prognoses that affect not only patients but also their families and caregivers. Patients with a variety of neurologic conditions such as Parkinson disease, dementia, amyotrophic lateral sclerosis, brain tumors, stroke, and acute neurologic illnesses have substantial unmet needs that can be addressed through a combination of primary and specialty palliative care.

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Twenty-First Century Precision Medicine in Oncology: Genomic Profiling in Patients With Cancer  Voir?

The advent of next-generation sequencing has accelerated the implementation of genomic profiling in the care and management of patients with cancer. Initial efforts have focused on target identification in patients with advanced cancer. Prognostication, resistance detection, disease monitoring, and early detection efforts are also underway. This review highlights some of the challenges in this evolving space. This includes choosing between gene-panel and comprehensive approaches, DNA and transcriptome data integration, reduction of false-positive variants, addressing tumor heterogeneity, establishment of workflows to address unsolicited findings, and data sharing and privacy concerns.

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Seventy Years of Management Engineering and Consulting: Integrating Health Care Delivery for an Enduring Mission  Voir?

On July 21, 2017, the Department of Management Engineering & Internal Consulting (ME&IC) celebrated its 70th anniversary. Over the years, this unique department has partnered with Mayo Clinic colleagues to achieve the best patient experience through objective, innovative, and integrative engineering and business consulting. The Department of Management Engineering & Internal Consulting collaborates with internal groups and external institutions to bring diverse expertise and collective excellence and to develop approaches and methods for the future.

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Management of Muscle-Invasive Urothelial Cancer and the Emerging Role of Immunotherapy in Advanced Urothelial Cancer  Voir?

The incidence of bladder cancer has increased in the past decade, and mortality from bladder cancer remains a substantial public health burden. After 3 decades of minimal progress in the treatment of advanced-stage disease, recent advances in the genomic characterization of urothelial cancer and breakthroughs in bladder cancer therapeutics have rejuvenated the field. This review highlights the landmark clinical trials of chemotherapy in both the neoadjuvant and advanced or metastatic urothelial carcinoma settings.

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Statin Use and Risk of Community-Acquired Staphylococcus aureus Bacteremia: A Population-Based Case-Control Study  Voir?

To ascertain whether persons treated with statins experience a decreased risk of community-acquired Staphylococcus aureus bacteremia (CA-SAB) as compared with nonusers.
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Medical Licensure Questions and Physician Reluctance to Seek Care for Mental Health Conditions  Voir?

To determine whether state medical licensure application questions (MLAQs) about mental health are related to physicians' reluctance to seek help for a mental health condition because of concerns about repercussions to their medical licensure.
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Individual and Combined Associations of Cognitive and Mobility Limitations on Mortality Risk in Older Adults  Voir?

To evaluate the potential independent and combined associations of cognitive and mobility limitations on risk of all-cause mortality in a representative sample of the US older adult population who, at baseline, were free of cardiovascular and cerebrovascular disease.
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Dernière mise à jour : 17/10/2017 : 08:05


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