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Sommaires des Revues - New England Journal of Medecine

The New England Journal of Medicine: Search Results in Neurology\Neurosurgery


The New England Journal of Medicine (NEJM) RSS feed -- Search Results in Neurology\Neurosurgery. NEJM (http://www.nejm.org) is a weekly general medical journal that publishes new medical research findings, review articles, and editorial opinion on a wide variety of topics of importance to biomedical science and clinical practice.


An Element of Unsteadiness  Voir?

Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information, sharing his or her reasoning with the reader (regular type). The authors’ commentary follows. Stage. A 61-year-old woman presented with…

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Hematopoietic Stem-Cell Gene Therapy for Cerebral Adrenoleukodystrophy  Voir?

Adrenoleukodystrophy is an X-linked genetic disease that is caused by a defect in the gene ABCD1 (ATP-binding cassette, subfamily D, member 1), which encodes the peroxisomal ABC half-transporter ALD protein. Mutations in ABCD1 result in abnormal breakdown of very-long-chain fatty acids, a process…

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Optimizing Treatment for Cerebral Adrenoleukodystrophy in the Era of Gene Therapy  Voir?

Adrenoleukodystrophy is a peroxisomal metabolic disorder that can be manifested by rapidly progressive cerebral demyelination (known as cerebral adrenoleukodystrophy) in affected boys and men. Untreated cerebral adrenoleukodystrophy causes severe disability or death approximately 2 years after its…

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Patent Foramen Ovale Closure or Anticoagulation vs. Antiplatelets after Stroke  Voir?

Case–control studies have shown an association between patent foramen ovale (PFO) and cryptogenic stroke, particularly among patients younger than 55 years of age and among patients with an associated atrial septal aneurysm or a substantial right-to-left interatrial shunt. The role of closure of…

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Long-Term Outcomes of Patent Foramen Ovale Closure or Medical Therapy after Stroke  Voir?

Between 20 and 30% of ischemic strokes are cryptogenic. A strong association between cryptogenic strokes and the presence of patent foramen ovale (PFO) suggests that paradoxical embolism through a PFO may be one important cause of otherwise unexplained infarcts. Percutaneous devices for closure of…

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Patent Foramen Ovale Closure or Antiplatelet Therapy for Cryptogenic Stroke  Voir?

Patent foramen ovale (PFO) is a potential cause of cryptogenic stroke. Three previous randomized trials of transcatheter PFO closure did not show a lower risk of recurrent stroke with PFO closure than with medical therapy in their primary intention-to-treat analyses; however, secondary analyses…

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Tipping Point for Patent Foramen Ovale Closure  Voir?

On the basis of what I had read previously in the Journal, I recently explained to my 44-year-old patient that closing his patent foramen ovale (PFO) after his stroke was not advisable. How can we now have three trials showing that closure prevents recurrent stroke, given that in the past 5 years,…

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Patent Foramen Ovale after Cryptogenic Stroke — Assessing the Evidence for Closure  Voir?

The Amplatzer PFO Occluder was approved by the Food and Drug Administration (FDA) on October 28, 2016. The device is indicated for percutaneous transcatheter closure of a patent foramen ovale to reduce the risk of recurrent ischemic stroke in patients who’ve had a cryptogenic stroke that a…

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Waving Hello to Noninvasive Deep-Brain Stimulation  Voir?

Disorders of brain function are leading causes of disease burden. The clinical manifestations of neurologic and psychiatric disorders are often caused by malfunction in circuits in the brain that regulate sensory, motor, cognitive, and behavioral functions. The signs and symptoms of the disorders…

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Vaccination Rates among Younger Siblings of Children with Autism  Voir?

To the Editor: Recent outbreaks of illnesses that may be prevented by vaccines have increased public debate about vaccination behaviors (i.e. whether or not and when parents choose to vaccinate a child), and California has been a key affected state. One reason that parents choose not to have their…

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Connecting the Dots  Voir?

Foreword. In this Journal feature, information about a real patient is presented in stages (boldface type) to an expert clinician, who responds to the information, sharing his or her reasoning with the reader (regular type). The authors’ commentary follows. Stage. A 46-year-old woman presented to…

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Porphyria  Voir?

Who remembers porphyria? For most health care providers, the name encompasses a group of diseases that were mentioned in a lecture and were too rare to commit to memory. However, the prevalence of some types of porphyria may be higher than is generally assumed. In this review, we discuss progress…

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Sturge–Weber Syndrome  Voir?

Figure 1.
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Abandonment  Voir?

"Hospice. It’s where people go to die," she says, surprising me with her sudden lucidity. "And also for symptom management," I add gently. "Like my headache," she notes. And your homelessness, I think — the fact that your one-bedroom, upstairs council flat just won’t do anymore. "I could go home,"…

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Cognitive Function in a Randomized Trial of Evolocumab  Voir?

Statin therapy, ezetimibe, and the proprotein convertase subtilisin–kexin type 9 (PCSK9) inhibitor evolocumab have been shown to reduce the rate of cardiovascular events among patients with established cardiovascular disease. These therapies may result in very low levels of low-density lipoprotein…

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Signs  Voir?

Not long after my mother died, my father lay disconsolate in a darkened hotel room begging his deceased wife to send him a sign. Wherever she was in her ghostly habitat, would she please smuggle him some affirmation of their enduring love? Suddenly, the overhead light switched on. Other people…

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Migraine  Voir?

Foreword. This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author’s clinical recommendations. Stage. A 23-year-old…

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Gabapentin and Pregabalin for Pain — Is Increased Prescribing a Cause for Concern?  Voir?

Treatment of chronic noncancer pain during the opioid epidemic has become challenging for clinicians. Patients want their pain to be adequately managed, and clinicians are searching for safe, effective alternatives to opioids. Recent guidelines from the Centers for Disease Control and Prevention…

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The Role of Science in Addressing the Opioid Crisis  Voir?

Opioid misuse and addiction is an ongoing and rapidly evolving public health crisis, requiring innovative scientific solutions. In response, and because no existing medication is ideal for every patient, the National Institutes of Health (NIH) is joining with private partners to launch an…
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Nystagmus from Wernicke’s Encephalopathy  Voir?

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Dernière mise à jour : 17/10/2017 : 07:09


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